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Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE
Motivation: Two methods are commonly used to report on evidence carried by forensic DNA profiles: the ‘Random Man Not Excluded’ (RMNE) approach and the likelihood ratio (LR) approach. It is often claimed a major advantage of the LR method that dropout can be assessed probabilistically. Results: In t...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639002/ https://www.ncbi.nlm.nih.gov/pubmed/19029128 http://dx.doi.org/10.1093/bioinformatics/btn608 |
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author | Van Nieuwerburgh, F. Goetghebeur, E. Vandewoestyne, M. Deforce, D. |
author_facet | Van Nieuwerburgh, F. Goetghebeur, E. Vandewoestyne, M. Deforce, D. |
author_sort | Van Nieuwerburgh, F. |
collection | PubMed |
description | Motivation: Two methods are commonly used to report on evidence carried by forensic DNA profiles: the ‘Random Man Not Excluded’ (RMNE) approach and the likelihood ratio (LR) approach. It is often claimed a major advantage of the LR method that dropout can be assessed probabilistically. Results: In this article, a new RMNE measure is proposed that like-wise accounts for allelic dropout in an observed forensic DNA profile. We discuss the necessary calculations, underline their simplicity and provide a tool for performing the calculations. Availability: An Excel file with preprogrammed calculations of RMNE probabilities for DNA profiles up to 16 loci and with a maximum of two dropouts is available at: http://www.labfbt.UGent.be/RMNE.php Contact: dieter.deforce@ugent.be |
format | Text |
id | pubmed-2639002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26390022009-02-25 Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE Van Nieuwerburgh, F. Goetghebeur, E. Vandewoestyne, M. Deforce, D. Bioinformatics Original Papers Motivation: Two methods are commonly used to report on evidence carried by forensic DNA profiles: the ‘Random Man Not Excluded’ (RMNE) approach and the likelihood ratio (LR) approach. It is often claimed a major advantage of the LR method that dropout can be assessed probabilistically. Results: In this article, a new RMNE measure is proposed that like-wise accounts for allelic dropout in an observed forensic DNA profile. We discuss the necessary calculations, underline their simplicity and provide a tool for performing the calculations. Availability: An Excel file with preprogrammed calculations of RMNE probabilities for DNA profiles up to 16 loci and with a maximum of two dropouts is available at: http://www.labfbt.UGent.be/RMNE.php Contact: dieter.deforce@ugent.be Oxford University Press 2009-01-15 2008-11-23 /pmc/articles/PMC2639002/ /pubmed/19029128 http://dx.doi.org/10.1093/bioinformatics/btn608 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Papers Van Nieuwerburgh, F. Goetghebeur, E. Vandewoestyne, M. Deforce, D. Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title | Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title_full | Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title_fullStr | Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title_full_unstemmed | Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title_short | Impact of allelic dropout on evidential value of forensic DNA profiles using RMNE |
title_sort | impact of allelic dropout on evidential value of forensic dna profiles using rmne |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639002/ https://www.ncbi.nlm.nih.gov/pubmed/19029128 http://dx.doi.org/10.1093/bioinformatics/btn608 |
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