Correlation of enhanced thrombospondin-1 expression, TGF-β signalling and proteinuria in human type-2 diabetic nephropathy

Background. Activation of the thrombospondin-1 (TSP-1)-TGF-β pathway by glucose and the relevance of TSP-1-dependent activation of TGF-β for renal matrix expansion, renal fibrosis and sclerosis have previously been demonstrated by our group in in vivo and in vitro studies. Design and methods. We inv...

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Detalles Bibliográficos
Autores principales: Hohenstein, Bernd, Daniel, Christoph, Hausknecht, Birgit, Boehmer, Kirsten, Riess, Regine, Amann, Kerstin U., Hugo, Christian P. M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Clinical Nephrology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639063/
https://www.ncbi.nlm.nih.gov/pubmed/18676351
http://dx.doi.org/10.1093/ndt/gfn399

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