Cargando…

Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21(Cip/WAF1 )pathway

BACKGROUND: Valproic acid (VPA), a commonly used mood stabilizer that promotes neuronal differentiation, regulates multiple signaling pathways involving extracellular signal-regulated kinase (ERK) and glycogen synthase kinase3β (GSK3β). However, the mechanism by which VPA promotes differentiation is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Gyung-Ah, Yoon, Ju-Yong, Moon, Byoung-San, Yang, Dong-Hwa, Kim, Hyun-Yi, Lee, Sang-Hun, Bryja, Vitezslav, Arenas, Ernest, Choi, Kang-Yell
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639384/ https://www.ncbi.nlm.nih.gov/pubmed/19068119 http://dx.doi.org/10.1186/1471-2121-9-66

Ejemplares similares

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
por: Jeong, Woo-Jeong, et al.
Publicado: (2018)

FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1)
por: Kloet, David E.A., et al.
Publicado: (2015)

Epigenetic Regulation of p21(cip1/waf1) in Human Cancer
por: Ocker, Matthias, et al.
Publicado: (2019)

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.
por: Koopmann, J., et al.
Publicado: (1995)

Expression of p21 (WAF1/CIP1) protein in clinical thyroid tissues.
por: Ito, Y., et al.
Publicado: (1996)

Regenerative Response in Ischemic Brain Restricted by p21(cip1/waf1)
por: Qiu, Jianhua, et al.
Publicado: (2004)

p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin
por: Molnar, Zoltan, et al.
Publicado: (2014)

Cell Cycle‐dependent Modulation of Promoter Activities of RB and WAF1/Cip1 Genes
por: Matsumoto, Takuji, et al.
Publicado: (1998)

TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response
por: Pisonero-Vaquero, Sandra, et al.
Publicado: (2020)

Lack of a p21(waf1/cip)-Dependent G1/S Checkpoint in Neural Stem and Progenitor Cells After DNA Damage In Vivo
por: Roque, Telma, et al.
Publicado: (2012)

EBV-positive Hodgkin lymphoma is associated with suppression of p21(cip1/waf1 )and a worse prognosis
por: Liu, Ting-Yun, et al.
Publicado: (2010)

The role of p21Waf1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma (Review).
por: Pérez-Sayáns, Mario, et al.
Publicado: (2013)

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells
por: Radaszkiewicz, Tomasz, et al.
Publicado: (2020)

WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.
por: Wan, M., et al.
Publicado: (1996)

Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma.
por: Ogawa, M., et al.
Publicado: (1997)

TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
por: Liu, Yuhui, et al.
Publicado: (2013)

Relationship between Expression of p21(WAF1/CIP1) and Radio resistance in Human Gliomas
por: Kokunai, Takashi, et al.
Publicado: (1999)

p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress
por: Manu, Kanjoormana Aryan, et al.
Publicado: (2019)

Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1
por: Zhang, Ying, et al.
Publicado: (2022)

p21(CIP/WAF1) saRNA inhibits proliferative vitreoretinopathy in a rabbit model
por: Zhang, Qi, et al.
Publicado: (2023)

Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
por: Tanaka, Hiroyuki, et al.
Publicado: (2002)

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
por: Phalke, Sameer, et al.
Publicado: (2012)

p21(WAF1/CIP1) RNA Expression in Highly HIV-1 Exposed, Uninfected Individuals
por: Herbeck, Joshua, et al.
Publicado: (2015)

By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer
por: Zhang, Qing, et al.
Publicado: (2015)

Splicing factor SRSF3 represses translation of p21(cip1/waf1) mRNA
por: Kim, Jeeho, et al.
Publicado: (2022)

Protective roles of cytoplasmic p21(Cip1) (/Waf1) in senolysis and ferroptosis of lung cancer cells
por: Koyanagi, Akira, et al.
Publicado: (2022)

MiTF links Erk1/2 kinase and p21(CIP1/WAF1 )activation after UVC radiation in normal human melanocytes and melanoma cells
por: Liu, Feng, et al.
Publicado: (2010)

Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells
por: Liu, X M, et al.
Publicado: (2003)

A human ribonuclease induces apoptosis associated with p21(WAF1/CIP1 )induction and JNK inactivation
por: Castro, Jessica, et al.
Publicado: (2011)

p300 Alters Keratinocyte Cell Growth and Differentiation through Regulation of p21(Waf1/CIP1)
por: Wong, Ping-Pui, et al.
Publicado: (2010)

Expression of p21(waf‐1/cip‐1) Is Significantly Induced in the Livers of LEC Rats with Chronic Liver Injury
por: Sawada, Norimasa, et al.
Publicado: (1996)

Lack of Evidence of Association of p21(WAF1/CIP1) Polymorphism with Lung Cancer Susceptibility and Prognosis in Taiwan
por: Shih, Chuen‐Ming, et al.
Publicado: (2000)

Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells
por: Kreis, Nina-Naomi, et al.
Publicado: (2019)

The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
por: Kreis, Nina-Naomi, et al.
Publicado: (2019)

Chloroquine reverses chemoresistance via upregulation of p21(WAF1/CIP1) and autophagy inhibition in ovarian cancer
por: Hwang, Jae Ryoung, et al.
Publicado: (2020)

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
por: Bernatik, Ondrej, et al.
Publicado: (2021)

Reduced p21(WAF1/CIP1)protein expression is predominantly related to altered p53 in hepatocellular carcinomas
por: Shi, Y-Z, et al.
Publicado: (2000)

Polymorphisms in the 5′ upstream regulatory region of p21(WAF1/CIP1) and susceptibility to oesophageal squamous cell carcinoma
por: Yang, Wenjun, et al.
Publicado: (2016)

Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21(Cip1/Waf1)
por: Qiu, L, et al.
Publicado: (2016)

Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner
por: Hu, Huanrong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mj8n4o2o3ntt41kjmj1mi3c03h