Challenge of conducting a placebo-controlled randomized efficacy study for influenza vaccine in a season with low attack rate and a mismatched vaccine B strain: a concrete example

BACKGROUND: Our aim was to determine the efficacy of a trivalent inactivated split virus influenza vaccine (TIV) against culture-confirmed influenza A and/or B in adults 18 to 64 years of age during the 2005/2006 season in the Czech Republic. METHODS: 6203 subjects were randomized to receive TIV (N...

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Detalles Bibliográficos
Autores principales: Beran, Jiří, Wertzova, Veronika, Honegr, Karel, Kaliskova, Eva, Havlickova, Martina, Havlik, Jiří, Jirincova, Helena, Van Belle, Pascale, Jain, Varsha, Innis, Bruce, Devaster, Jeanne-Marie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639595/
https://www.ncbi.nlm.nih.gov/pubmed/19149900
http://dx.doi.org/10.1186/1471-2334-9-2

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