The D4Z4 Macrosatellite Repeat Acts as a CTCF and A-Type Lamins-Dependent Insulator in Facio-Scapulo-Humeral Dystrophy

Both genetic and epigenetic alterations contribute to Facio-Scapulo-Humeral Dystrophy (FSHD), which is linked to the shortening of the array of D4Z4 repeats at the 4q35 locus. The consequence of this rearrangement remains enigmatic, but deletion of this 3.3-kb macrosatellite element might affect the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ottaviani, Alexandre, Rival-Gervier, Sylvie, Boussouar, Amina, Foerster, Andrea M., Rondier, Delphine, Sacconi, Sabrina, Desnuelle, Claude, Gilson, Eric, Magdinier, Frédérique
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639723/
https://www.ncbi.nlm.nih.gov/pubmed/19247430
http://dx.doi.org/10.1371/journal.pgen.1000394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639723/
https://www.ncbi.nlm.nih.gov/pubmed/19247430
http://dx.doi.org/10.1371/journal.pgen.1000394

Ejemplares similares