Cargando…
Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.
Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculo...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
1998
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640153/ https://www.ncbi.nlm.nih.gov/pubmed/9621190 |
_version_ | 1782164534435250176 |
---|---|
author | Rattan, A Kalia, A Ahmad, N |
author_facet | Rattan, A Kalia, A Ahmad, N |
author_sort | Rattan, A |
collection | PubMed |
description | Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction. |
format | Text |
id | pubmed-2640153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26401532009-05-20 Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. Rattan, A Kalia, A Ahmad, N Emerg Infect Dis Research Article Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction. Centers for Disease Control and Prevention 1998 /pmc/articles/PMC2640153/ /pubmed/9621190 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Article Rattan, A Kalia, A Ahmad, N Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title | Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title_full | Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title_fullStr | Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title_full_unstemmed | Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title_short | Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives. |
title_sort | multidrug-resistant mycobacterium tuberculosis: molecular perspectives. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640153/ https://www.ncbi.nlm.nih.gov/pubmed/9621190 |
work_keys_str_mv | AT rattana multidrugresistantmycobacteriumtuberculosismolecularperspectives AT kaliaa multidrugresistantmycobacteriumtuberculosismolecularperspectives AT ahmadn multidrugresistantmycobacteriumtuberculosismolecularperspectives |