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Cell-to-cell signaling and Pseudomonas aeruginosa infections.
Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cel...
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640238/ https://www.ncbi.nlm.nih.gov/pubmed/9866731 |
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author | Van Delden, C Iglewski, B H |
author_facet | Van Delden, C Iglewski, B H |
author_sort | Van Delden, C |
collection | PubMed |
description | Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cell-to-cell signaling systems control the expression and allow a coordinated, cell-density-dependent production of many extracellular virulence factors. We discuss the possible role of cell-to-cell signaling in the pathogenesis of P. aeruginosa infections and present a rationale for targeting cell-to-cell signaling systems in the development of new therapeutic approaches. |
format | Text |
id | pubmed-2640238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26402382009-05-20 Cell-to-cell signaling and Pseudomonas aeruginosa infections. Van Delden, C Iglewski, B H Emerg Infect Dis Research Article Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cell-to-cell signaling systems control the expression and allow a coordinated, cell-density-dependent production of many extracellular virulence factors. We discuss the possible role of cell-to-cell signaling in the pathogenesis of P. aeruginosa infections and present a rationale for targeting cell-to-cell signaling systems in the development of new therapeutic approaches. Centers for Disease Control and Prevention 1998 /pmc/articles/PMC2640238/ /pubmed/9866731 Text en |
spellingShingle | Research Article Van Delden, C Iglewski, B H Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title | Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title_full | Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title_fullStr | Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title_full_unstemmed | Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title_short | Cell-to-cell signaling and Pseudomonas aeruginosa infections. |
title_sort | cell-to-cell signaling and pseudomonas aeruginosa infections. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640238/ https://www.ncbi.nlm.nih.gov/pubmed/9866731 |
work_keys_str_mv | AT vandeldenc celltocellsignalingandpseudomonasaeruginosainfections AT iglewskibh celltocellsignalingandpseudomonasaeruginosainfections |