C/EBPα or C/EBPα oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-κB p50 bound to the bcl-2 and FLIP gene promoters

CCAAT/enhancer binding protein α (C/EBPα) is mutated in 10% of acute myeloid leukemias, resulting in either a truncated protein or an altered leucine zipper (C/EBPαLZ) that prevents DNA-binding. C/EBPα induces bcl-2 in cooperation with NF-κB p50 to inhibit apoptosis. We now demostrate that C/EBPα or...

Descripción completa

Detalles Bibliográficos
Autores principales: Paz-Priel, I, Ghosal, AK, Kowalski, J, Friedman, AD
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640433/
https://www.ncbi.nlm.nih.gov/pubmed/18987666
http://dx.doi.org/10.1038/leu.2008.297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640433/
https://www.ncbi.nlm.nih.gov/pubmed/18987666
http://dx.doi.org/10.1038/leu.2008.297

Ejemplares similares