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Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya.
We examined the long-term efficacy of praziquantel against Schistosoma haematobium, the causative agent of urinary schistosomiasis, during a school-based treatment program in the Msambweni area of Coast Province, Kenya, where the disease is highly endemic. Our results, derived from treating 4,031 of...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640915/ https://www.ncbi.nlm.nih.gov/pubmed/11076716 |
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author | King, C H Muchiri, E M Ouma, J H |
author_facet | King, C H Muchiri, E M Ouma, J H |
author_sort | King, C H |
collection | PubMed |
description | We examined the long-term efficacy of praziquantel against Schistosoma haematobium, the causative agent of urinary schistosomiasis, during a school-based treatment program in the Msambweni area of Coast Province, Kenya, where the disease is highly endemic. Our results, derived from treating 4,031 of 7,641 children from 1984 to 1993, indicate substantial year-to- year variation in drug efficacy. However, the pattern of this variation was not consistent with primary or progressive emergence of praziquantel resistance. Mathematical modeling indicated that, at current treatment rates, praziquantel resistance will likely take 10 or more years to emerge. |
format | Text |
id | pubmed-2640915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26409152009-05-20 Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. King, C H Muchiri, E M Ouma, J H Emerg Infect Dis Research Article We examined the long-term efficacy of praziquantel against Schistosoma haematobium, the causative agent of urinary schistosomiasis, during a school-based treatment program in the Msambweni area of Coast Province, Kenya, where the disease is highly endemic. Our results, derived from treating 4,031 of 7,641 children from 1984 to 1993, indicate substantial year-to- year variation in drug efficacy. However, the pattern of this variation was not consistent with primary or progressive emergence of praziquantel resistance. Mathematical modeling indicated that, at current treatment rates, praziquantel resistance will likely take 10 or more years to emerge. Centers for Disease Control and Prevention 2000 /pmc/articles/PMC2640915/ /pubmed/11076716 Text en |
spellingShingle | Research Article King, C H Muchiri, E M Ouma, J H Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title | Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title_full | Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title_fullStr | Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title_full_unstemmed | Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title_short | Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. |
title_sort | evidence against rapid emergence of praziquantel resistance in schistosoma haematobium, kenya. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640915/ https://www.ncbi.nlm.nih.gov/pubmed/11076716 |
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