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Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion with increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific CD8 T cells from the liver (the site of viral replication) display increased PD-1 expression and a profound functional impairment th...

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Detalles Bibliográficos
Autores principales:	Nakamoto, Nobuhiro, Cho, Hyosun, Shaked, Abraham, Olthoff, Kim, Valiga, Mary E., Kaminski, Mary, Gostick, Emma, Price, David A., Freeman, Gordon J., Wherry, E. John, Chang, Kyong-Mi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642724/ https://www.ncbi.nlm.nih.gov/pubmed/19247441 http://dx.doi.org/10.1371/journal.ppat.1000313

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