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Creutzfeldt-Jacob disease presenting as severe depression: a case report

BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive de...

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Detalles Bibliográficos
Autores principales: Cumbler, Ethan, Furfari, Kristin, Guerrasio, Jeannette
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642786/
https://www.ncbi.nlm.nih.gov/pubmed/19193205
http://dx.doi.org/10.1186/1757-1626-2-122
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author Cumbler, Ethan
Furfari, Kristin
Guerrasio, Jeannette
author_facet Cumbler, Ethan
Furfari, Kristin
Guerrasio, Jeannette
author_sort Cumbler, Ethan
collection PubMed
description BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive decline. Initial working hypothesis was serotonin syndrome or neuroleptic malignant syndrome but continued deterioration after medication removal prompted evaluation for alternative etiology. Work-up revealed elevated 14-3-3 CSF protein which suggested the prion disorder which was confirmed on post-mortem examination of brain tissue. CONCLUSION: While the degree of depression was unusually severe, the case highlights the behavioral and psychiatric manifestations which frequently accompany Creutzfeldt-Jacob disease.
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spelling pubmed-26427862009-02-14 Creutzfeldt-Jacob disease presenting as severe depression: a case report Cumbler, Ethan Furfari, Kristin Guerrasio, Jeannette Cases J Case Report BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive decline. Initial working hypothesis was serotonin syndrome or neuroleptic malignant syndrome but continued deterioration after medication removal prompted evaluation for alternative etiology. Work-up revealed elevated 14-3-3 CSF protein which suggested the prion disorder which was confirmed on post-mortem examination of brain tissue. CONCLUSION: While the degree of depression was unusually severe, the case highlights the behavioral and psychiatric manifestations which frequently accompany Creutzfeldt-Jacob disease. BioMed Central 2009-02-04 /pmc/articles/PMC2642786/ /pubmed/19193205 http://dx.doi.org/10.1186/1757-1626-2-122 Text en Copyright ©2009 Cumbler et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cumbler, Ethan
Furfari, Kristin
Guerrasio, Jeannette
Creutzfeldt-Jacob disease presenting as severe depression: a case report
title Creutzfeldt-Jacob disease presenting as severe depression: a case report
title_full Creutzfeldt-Jacob disease presenting as severe depression: a case report
title_fullStr Creutzfeldt-Jacob disease presenting as severe depression: a case report
title_full_unstemmed Creutzfeldt-Jacob disease presenting as severe depression: a case report
title_short Creutzfeldt-Jacob disease presenting as severe depression: a case report
title_sort creutzfeldt-jacob disease presenting as severe depression: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642786/
https://www.ncbi.nlm.nih.gov/pubmed/19193205
http://dx.doi.org/10.1186/1757-1626-2-122
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