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Creutzfeldt-Jacob disease presenting as severe depression: a case report
BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive de...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642786/ https://www.ncbi.nlm.nih.gov/pubmed/19193205 http://dx.doi.org/10.1186/1757-1626-2-122 |
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author | Cumbler, Ethan Furfari, Kristin Guerrasio, Jeannette |
author_facet | Cumbler, Ethan Furfari, Kristin Guerrasio, Jeannette |
author_sort | Cumbler, Ethan |
collection | PubMed |
description | BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive decline. Initial working hypothesis was serotonin syndrome or neuroleptic malignant syndrome but continued deterioration after medication removal prompted evaluation for alternative etiology. Work-up revealed elevated 14-3-3 CSF protein which suggested the prion disorder which was confirmed on post-mortem examination of brain tissue. CONCLUSION: While the degree of depression was unusually severe, the case highlights the behavioral and psychiatric manifestations which frequently accompany Creutzfeldt-Jacob disease. |
format | Text |
id | pubmed-2642786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26427862009-02-14 Creutzfeldt-Jacob disease presenting as severe depression: a case report Cumbler, Ethan Furfari, Kristin Guerrasio, Jeannette Cases J Case Report BACKGROUND: An 81 year old female presented with altered mental status after new onset of severe depression and suicidal ideation with recent psychiatric hospitalization. CASE PRESENTATION: Key clinical features included muscle rigidity, prominent startle reflex, and rapidly progressing cognitive decline. Initial working hypothesis was serotonin syndrome or neuroleptic malignant syndrome but continued deterioration after medication removal prompted evaluation for alternative etiology. Work-up revealed elevated 14-3-3 CSF protein which suggested the prion disorder which was confirmed on post-mortem examination of brain tissue. CONCLUSION: While the degree of depression was unusually severe, the case highlights the behavioral and psychiatric manifestations which frequently accompany Creutzfeldt-Jacob disease. BioMed Central 2009-02-04 /pmc/articles/PMC2642786/ /pubmed/19193205 http://dx.doi.org/10.1186/1757-1626-2-122 Text en Copyright ©2009 Cumbler et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Cumbler, Ethan Furfari, Kristin Guerrasio, Jeannette Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title | Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title_full | Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title_fullStr | Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title_full_unstemmed | Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title_short | Creutzfeldt-Jacob disease presenting as severe depression: a case report |
title_sort | creutzfeldt-jacob disease presenting as severe depression: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642786/ https://www.ncbi.nlm.nih.gov/pubmed/19193205 http://dx.doi.org/10.1186/1757-1626-2-122 |
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