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Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage

BACKGROUND: While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinas...

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Autores principales: Wilson, Jacob M, Kim, Jeong-su, Lee, Sang-rok, Rathmacher, John A, Dalmau, Brett, Kingsley, J Derek, Koch, Heather, Manninen, Anssi H, Saadat, Raz, Panton, Lynn B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642830/
https://www.ncbi.nlm.nih.gov/pubmed/19193206
http://dx.doi.org/10.1186/1743-7075-6-6
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author Wilson, Jacob M
Kim, Jeong-su
Lee, Sang-rok
Rathmacher, John A
Dalmau, Brett
Kingsley, J Derek
Koch, Heather
Manninen, Anssi H
Saadat, Raz
Panton, Lynn B
author_facet Wilson, Jacob M
Kim, Jeong-su
Lee, Sang-rok
Rathmacher, John A
Dalmau, Brett
Kingsley, J Derek
Koch, Heather
Manninen, Anssi H
Saadat, Raz
Panton, Lynn B
author_sort Wilson, Jacob M
collection PubMed
description BACKGROUND: While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). METHODS: Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design, all subjects performed 55 maximal eccentric knee extension/flexion contractions on 2 occasions on either the right or left leg. HMB-Pre (N = 8) randomly received 3 grams of either a placebo or HMB before and a placebo after exercise. HMB-Post (N = 8) received a placebo before and either 3 grams of HMB or a placebo after exercise. Muscle damage tests were recorded before, at 8, 24, 48, and 72 hrs post exercise. RESULTS: There was a reduction in MVC and an increase in soreness in the quadriceps and hamstrings following exercise (p < 0.001). Although HMB-Pre approached significance in attenuating soreness for the quadriceps (p = 0.07), there was no time × group effect. Serum indices of damage increased, peaking at 48 hrs for CK (773%) (p < 0.001) and 72 hrs for LDH (180%) (p < 0.001). While there were no time × group effects of HMB on CK and LDH, post hoc analysis revealed that only HMB-Pre showed no significant increase in LDH levels following exercise. CONCLUSION: Our findings suggest no clear acute or timing effects of HMB supplementation. However, consuming HMB before exercise appeared to prevent increases in LDH.
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spelling pubmed-26428302009-02-14 Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage Wilson, Jacob M Kim, Jeong-su Lee, Sang-rok Rathmacher, John A Dalmau, Brett Kingsley, J Derek Koch, Heather Manninen, Anssi H Saadat, Raz Panton, Lynn B Nutr Metab (Lond) Research BACKGROUND: While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). METHODS: Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design, all subjects performed 55 maximal eccentric knee extension/flexion contractions on 2 occasions on either the right or left leg. HMB-Pre (N = 8) randomly received 3 grams of either a placebo or HMB before and a placebo after exercise. HMB-Post (N = 8) received a placebo before and either 3 grams of HMB or a placebo after exercise. Muscle damage tests were recorded before, at 8, 24, 48, and 72 hrs post exercise. RESULTS: There was a reduction in MVC and an increase in soreness in the quadriceps and hamstrings following exercise (p < 0.001). Although HMB-Pre approached significance in attenuating soreness for the quadriceps (p = 0.07), there was no time × group effect. Serum indices of damage increased, peaking at 48 hrs for CK (773%) (p < 0.001) and 72 hrs for LDH (180%) (p < 0.001). While there were no time × group effects of HMB on CK and LDH, post hoc analysis revealed that only HMB-Pre showed no significant increase in LDH levels following exercise. CONCLUSION: Our findings suggest no clear acute or timing effects of HMB supplementation. However, consuming HMB before exercise appeared to prevent increases in LDH. BioMed Central 2009-02-04 /pmc/articles/PMC2642830/ /pubmed/19193206 http://dx.doi.org/10.1186/1743-7075-6-6 Text en Copyright © 2009 Wilson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wilson, Jacob M
Kim, Jeong-su
Lee, Sang-rok
Rathmacher, John A
Dalmau, Brett
Kingsley, J Derek
Koch, Heather
Manninen, Anssi H
Saadat, Raz
Panton, Lynn B
Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title_full Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title_fullStr Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title_full_unstemmed Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title_short Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
title_sort acute and timing effects of beta-hydroxy-beta-methylbutyrate (hmb) on indirect markers of skeletal muscle damage
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642830/
https://www.ncbi.nlm.nih.gov/pubmed/19193206
http://dx.doi.org/10.1186/1743-7075-6-6
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