Integrated Genomic Analysis Implicates Haploinsufficiency of Multiple Chromosome 5q31.2 Genes in De Novo Myelodysplastic Syndromes Pathogenesis

Deletions spanning chromosome 5q31.2 are among the most common recurring cytogenetic abnormalities detectable in myelodysplastic syndromes (MDS). Prior genomic studies have suggested that haploinsufficiency of multiple 5q31.2 genes may contribute to MDS pathogenesis. However, this hypothesis has nev...

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Detalles Bibliográficos
Autores principales: Graubert, Timothy A., Payton, Michelle A., Shao, Jin, Walgren, Richard A., Monahan, Ryan S., Frater, John L., Walshauser, Mark A., Martin, Mike G., Kasai, Yumi, Walter, Matthew J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642994/
https://www.ncbi.nlm.nih.gov/pubmed/19240791
http://dx.doi.org/10.1371/journal.pone.0004583

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