Is Altruistic Behavior Associated with Major Depression Onset?

BACKGROUND: Previous cross-sectional study showed altruistic behaviors were harmful on major depression (MD). It is needed to investigate the impact of altruistic behaviors by its contents on the development of MD prospectively. METHODOLOGY/PRINCIPAL FINDINGS: The National Survey of Midlife Development in the United States (MIDUS) in 1995–1996 and the MIDUS Psychological Experience Follow-Up study in 1998 were analyzed (weighted N = 563). Financial support of 10 or more dollars per month had a significant impact on the development of MD in comparison to no financial support (OR: 2.64, 95% CI: 1.05–6.62). Unpaid assistance and providing emotional support were not significantly associated with the development of MD in later life. CONCLUSIONS/SIGNIFICANCES: Those who provide financial contribution to individuals other than family members can be at risk of developing MD.