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Stromal control of oncogenic traits expressed in response to overexpression of GLI2, a pleiotropic oncogene
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. Overexpression induces genomic instability and blocks differentiation, likely mediated in part by enha...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643346/ https://www.ncbi.nlm.nih.gov/pubmed/19015636 http://dx.doi.org/10.1038/onc.2008.421 |