Cargando…

Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement

Objective To examine the association between a biomarker of exposure to secondhand smoke (salivary cotinine concentration) and cognitive impairment. Design Cross sectional analysis of a national population based study. Setting Stratified random sample of households throughout England. Participants 4...

Descripción completa

Detalles Bibliográficos
Autores principales: Llewellyn, David J, Lang, Iain A, Langa, Kenneth M, Naughton, Felix, Matthews, Fiona E
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643443/
https://www.ncbi.nlm.nih.gov/pubmed/19213767
http://dx.doi.org/10.1136/bmj.b462
_version_ 1782164694333652992
author Llewellyn, David J
Lang, Iain A
Langa, Kenneth M
Naughton, Felix
Matthews, Fiona E
author_facet Llewellyn, David J
Lang, Iain A
Langa, Kenneth M
Naughton, Felix
Matthews, Fiona E
author_sort Llewellyn, David J
collection PubMed
description Objective To examine the association between a biomarker of exposure to secondhand smoke (salivary cotinine concentration) and cognitive impairment. Design Cross sectional analysis of a national population based study. Setting Stratified random sample of households throughout England. Participants 4809 non-smoking adults aged 50 years or more from the 1998, 1999, and 2001 waves of the Health Survey for England who also participated in the 2002 wave of the English Longitudinal Study of Ageing and provided saliva samples for cotinine assay and a detailed smoking history. Main outcome measure Cognitive impairment as defined by the lowest 10% of scores on a battery of neuropsychological tests. Results Participants who did not smoke, use nicotine products, or have salivary cotinine concentrations of 14.1 ng/ml or more were divided into four equal size groups on the basis of cotinine concentrations. Compared with the lowest fourth of cotinine concentration (0.0-0.1 ng/ml) the odds ratios (95% confidence intervals) for cognitive impairment in the second (0.2-0.3 ng/ml), third (0.4-0.7 ng/ml), and highest fourths (0.8-13.5 ng/ml) were 1.08 (0.78 to 1.48), 1.13 (0.81 to 1.56), and 1.44 (1.07 to 1.94; P for trend 0.02), after adjustment for a wide range of established risk factors for cognitive impairment. A similar pattern of associations was observed for never smokers and former smokers. Conclusions Exposure to secondhand smoke may be associated with increased odds of cognitive impairment. Prospective nationally representative studies relating biomarkers of exposure to cognitive decline and risk of dementia are needed.
format Text
id pubmed-2643443
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BMJ Publishing Group Ltd.
record_format MEDLINE/PubMed
spelling pubmed-26434432009-02-17 Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement Llewellyn, David J Lang, Iain A Langa, Kenneth M Naughton, Felix Matthews, Fiona E BMJ Research Objective To examine the association between a biomarker of exposure to secondhand smoke (salivary cotinine concentration) and cognitive impairment. Design Cross sectional analysis of a national population based study. Setting Stratified random sample of households throughout England. Participants 4809 non-smoking adults aged 50 years or more from the 1998, 1999, and 2001 waves of the Health Survey for England who also participated in the 2002 wave of the English Longitudinal Study of Ageing and provided saliva samples for cotinine assay and a detailed smoking history. Main outcome measure Cognitive impairment as defined by the lowest 10% of scores on a battery of neuropsychological tests. Results Participants who did not smoke, use nicotine products, or have salivary cotinine concentrations of 14.1 ng/ml or more were divided into four equal size groups on the basis of cotinine concentrations. Compared with the lowest fourth of cotinine concentration (0.0-0.1 ng/ml) the odds ratios (95% confidence intervals) for cognitive impairment in the second (0.2-0.3 ng/ml), third (0.4-0.7 ng/ml), and highest fourths (0.8-13.5 ng/ml) were 1.08 (0.78 to 1.48), 1.13 (0.81 to 1.56), and 1.44 (1.07 to 1.94; P for trend 0.02), after adjustment for a wide range of established risk factors for cognitive impairment. A similar pattern of associations was observed for never smokers and former smokers. Conclusions Exposure to secondhand smoke may be associated with increased odds of cognitive impairment. Prospective nationally representative studies relating biomarkers of exposure to cognitive decline and risk of dementia are needed. BMJ Publishing Group Ltd. 2009-02-12 /pmc/articles/PMC2643443/ /pubmed/19213767 http://dx.doi.org/10.1136/bmj.b462 Text en © Llewellyn et al 2009 http://creativecommons.org/licenses/by-nc/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Llewellyn, David J
Lang, Iain A
Langa, Kenneth M
Naughton, Felix
Matthews, Fiona E
Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title_full Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title_fullStr Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title_full_unstemmed Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title_short Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
title_sort exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643443/
https://www.ncbi.nlm.nih.gov/pubmed/19213767
http://dx.doi.org/10.1136/bmj.b462
work_keys_str_mv AT llewellyndavidj exposuretosecondhandsmokeandcognitiveimpairmentinnonsmokersnationalcrosssectionalstudywithcotininemeasurement
AT langiaina exposuretosecondhandsmokeandcognitiveimpairmentinnonsmokersnationalcrosssectionalstudywithcotininemeasurement
AT langakennethm exposuretosecondhandsmokeandcognitiveimpairmentinnonsmokersnationalcrosssectionalstudywithcotininemeasurement
AT naughtonfelix exposuretosecondhandsmokeandcognitiveimpairmentinnonsmokersnationalcrosssectionalstudywithcotininemeasurement
AT matthewsfionae exposuretosecondhandsmokeandcognitiveimpairmentinnonsmokersnationalcrosssectionalstudywithcotininemeasurement