Cargando…
Mechanism of Action of Cyclophilin A Explored by Metadynamics Simulations
Trans/cis prolyl isomerisation is involved in several biological processes, including the development of numerous diseases. In the HIV-1 capsid protein (CA), such a process takes place in the uncoating and recruitment of the virion and is catalyzed by cyclophilin A (CypA). Here, we use metadynamics...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643488/ https://www.ncbi.nlm.nih.gov/pubmed/19282959 http://dx.doi.org/10.1371/journal.pcbi.1000309 |