Cargando…

Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of ‘executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of...

Descripción completa

Detalles Bibliográficos
Autores principales: Csikász-Nagy, Attila, Kapuy, Orsolya, Tóth, Attila, Pál, Csaba, Jensen, Lars Juhl, Uhlmann, Frank, Tyson, John J, Novák, Béla
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644172/
https://www.ncbi.nlm.nih.gov/pubmed/19156128
http://dx.doi.org/10.1038/msb.2008.73
_version_ 1782164707269935104
author Csikász-Nagy, Attila
Kapuy, Orsolya
Tóth, Attila
Pál, Csaba
Jensen, Lars Juhl
Uhlmann, Frank
Tyson, John J
Novák, Béla
author_facet Csikász-Nagy, Attila
Kapuy, Orsolya
Tóth, Attila
Pál, Csaba
Jensen, Lars Juhl
Uhlmann, Frank
Tyson, John J
Novák, Béla
author_sort Csikász-Nagy, Attila
collection PubMed
description The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of ‘executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or −) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence.
format Text
id pubmed-2644172
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-26441722009-02-19 Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation Csikász-Nagy, Attila Kapuy, Orsolya Tóth, Attila Pál, Csaba Jensen, Lars Juhl Uhlmann, Frank Tyson, John J Novák, Béla Mol Syst Biol Report The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of ‘executor' proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or −) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence. Nature Publishing Group 2009-01-20 /pmc/articles/PMC2644172/ /pubmed/19156128 http://dx.doi.org/10.1038/msb.2008.73 Text en Copyright © 2009, EMBO and Nature Publishing Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.
spellingShingle Report
Csikász-Nagy, Attila
Kapuy, Orsolya
Tóth, Attila
Pál, Csaba
Jensen, Lars Juhl
Uhlmann, Frank
Tyson, John J
Novák, Béla
Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title_full Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title_fullStr Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title_full_unstemmed Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title_short Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
title_sort cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644172/
https://www.ncbi.nlm.nih.gov/pubmed/19156128
http://dx.doi.org/10.1038/msb.2008.73
work_keys_str_mv AT csikasznagyattila cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT kapuyorsolya cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT tothattila cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT palcsaba cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT jensenlarsjuhl cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT uhlmannfrank cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT tysonjohnj cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation
AT novakbela cellcycleregulationbyfeedforwardloopscouplingtranscriptionandphosphorylation