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Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angi...

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Detalles Bibliográficos
Autores principales: Goldstein, Mark G, Li, Zihai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644312/
https://www.ncbi.nlm.nih.gov/pubmed/19183457
http://dx.doi.org/10.1186/1756-8722-2-5
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author Goldstein, Mark G
Li, Zihai
author_facet Goldstein, Mark G
Li, Zihai
author_sort Goldstein, Mark G
collection PubMed
description Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angiogenesis, tumor tolerance and metastatic properties of neoplasms. Recently, heat-shock proteins have been identified as mediators of this inflammatory process and thus may provide a link between infection-mediated inflammation and subsequent cancer development. In this review, the role of heat-shock proteins in infection-induced inflammation and carcinogenesis will be discussed.
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spelling pubmed-26443122009-02-18 Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis Goldstein, Mark G Li, Zihai J Hematol Oncol Review Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angiogenesis, tumor tolerance and metastatic properties of neoplasms. Recently, heat-shock proteins have been identified as mediators of this inflammatory process and thus may provide a link between infection-mediated inflammation and subsequent cancer development. In this review, the role of heat-shock proteins in infection-induced inflammation and carcinogenesis will be discussed. BioMed Central 2009-01-30 /pmc/articles/PMC2644312/ /pubmed/19183457 http://dx.doi.org/10.1186/1756-8722-2-5 Text en Copyright © 2009 Goldstein and Li; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Goldstein, Mark G
Li, Zihai
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title_full Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title_fullStr Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title_full_unstemmed Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title_short Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
title_sort heat-shock proteins in infection-mediated inflammation-induced tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644312/
https://www.ncbi.nlm.nih.gov/pubmed/19183457
http://dx.doi.org/10.1186/1756-8722-2-5
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