Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan

Spinal muscular atrophy is the most common genetic cause of infant mortality and is characterized by degeneration of lower motor neurons leading to muscle wasting. The causative gene has been identified as survival motor neuron (SMN). The invertebrate model organism Caenorhabditis elegans contains s...

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Detalles Bibliográficos
Autores principales: Briese, Michael, Esmaeili, Behrooz, Fraboulet, Sandrine, Burt, Emma C., Christodoulou, Stefanos, Towers, Paula R., Davies, Kay E., Sattelle, David B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644645/
https://www.ncbi.nlm.nih.gov/pubmed/18829666
http://dx.doi.org/10.1093/hmg/ddn320

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