Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

BACKGROUND: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expre...

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Detalles Bibliográficos
Autores principales: Cullen, Valerie, Lindfors, Maria, Ng, Juliana, Paetau, Anders, Swinton, Erika, Kolodziej, Piotr, Boston, Heather, Saftig, Paul, Woulfe, John, Feany, Mel B, Myllykangas, Liisa, Schlossmacher, Michael G, Tyynelä, Jaana
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644690/
https://www.ncbi.nlm.nih.gov/pubmed/19203374
http://dx.doi.org/10.1186/1756-6606-2-5

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