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Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction
BACKGROUND: Expansion of a polyglutamine repeat at the amino-terminus of huntingtin is the probable cause for Huntington's disease, a lethal progressive autosomal-dominant neurodegenerative disorders characterized by impaired motor performance and severe brain atrophy. The expanded polyglutamin...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644693/ https://www.ncbi.nlm.nih.gov/pubmed/19203385 http://dx.doi.org/10.1186/1750-1326-4-11 |