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Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

BACKGROUND: Expansion of a polyglutamine repeat at the amino-terminus of huntingtin is the probable cause for Huntington's disease, a lethal progressive autosomal-dominant neurodegenerative disorders characterized by impaired motor performance and severe brain atrophy. The expanded polyglutamin...

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Detalles Bibliográficos
Autores principales:	Weiss, Andreas, Roscic, Ana, Paganetti, Paolo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644693/ https://www.ncbi.nlm.nih.gov/pubmed/19203385 http://dx.doi.org/10.1186/1750-1326-4-11

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