MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four...

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Autores principales: Houzet, Laurent, Yeung, Man Lung, de Lame, Valery, Desai, Dhara, Smith, Stephen M, Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644721/
https://www.ncbi.nlm.nih.gov/pubmed/19114009
http://dx.doi.org/10.1186/1742-4690-5-118
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author Houzet, Laurent
Yeung, Man Lung
de Lame, Valery
Desai, Dhara
Smith, Stephen M
Jeang, Kuan-Teh
author_facet Houzet, Laurent
Yeung, Man Lung
de Lame, Valery
Desai, Dhara
Smith, Stephen M
Jeang, Kuan-Teh
author_sort Houzet, Laurent
collection PubMed
description MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
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spelling pubmed-26447212009-02-19 MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals Houzet, Laurent Yeung, Man Lung de Lame, Valery Desai, Dhara Smith, Stephen M Jeang, Kuan-Teh Retrovirology Research MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes. BioMed Central 2008-12-29 /pmc/articles/PMC2644721/ /pubmed/19114009 http://dx.doi.org/10.1186/1742-4690-5-118 Text en Copyright © 2008 Houzet et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Houzet, Laurent
Yeung, Man Lung
de Lame, Valery
Desai, Dhara
Smith, Stephen M
Jeang, Kuan-Teh
MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title_full MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title_fullStr MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title_full_unstemmed MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title_short MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
title_sort microrna profile changes in human immunodeficiency virus type 1 (hiv-1) seropositive individuals
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644721/
https://www.ncbi.nlm.nih.gov/pubmed/19114009
http://dx.doi.org/10.1186/1742-4690-5-118
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