PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with respiratory chain complexes in sucrose gradients...

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Detalles Bibliográficos
Autores principales: Liu, Wencheng, Vives-Bauza, Cristofol, Acín-Peréz-, Rebeca, Yamamoto, Ai, Tan, Yingcai, Li, Yanping, Magrané, Jordi, Stavarache, Mihaela A., Shaffer, Sebastian, Chang, Simon, Kaplitt, Michael G., Huang, Xin-Yun, Beal, M. Flint, Manfredi, Giovanni, Li, Chenjian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644779/
https://www.ncbi.nlm.nih.gov/pubmed/19242547
http://dx.doi.org/10.1371/journal.pone.0004597

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