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DNA instability in replicating Huntington's disease lymphoblasts

BACKGROUND: The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e.g. triplet mosaicism) in repeat length, the longest mutations involving mitotic (germ and glial cells) and postmitotic (neurons) cells. What contributes to the triplet mutability...

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Detalles Bibliográficos
Autores principales:	Cannella, Milena, Maglione, Vittorio, Martino, Tiziana, Ragona, Giuseppe, Frati, Luigi, Li, Guo-Min, Squitieri, Ferdinando
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645380/ https://www.ncbi.nlm.nih.gov/pubmed/19210789 http://dx.doi.org/10.1186/1471-2350-10-11

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