Biodistribution and clearance of instilled carbon nanotubes in rat lung

BACKGROUND: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. METHODS: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel,...

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Detalles Bibliográficos
Autores principales: Elgrabli, Dan, Floriani, Magali, Abella-Gallart, Steve, Meunier, Laurent, Gamez, Christelle, Delalain, Patrice, Rogerieux, Françoise, Boczkowski, Jorge, Lacroix, Ghislaine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645433/
https://www.ncbi.nlm.nih.gov/pubmed/19068117
http://dx.doi.org/10.1186/1743-8977-5-20
Descripción
Sumario:BACKGROUND: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. METHODS: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. RESULTS AND CONCLUSION: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.

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