Biodistribution and clearance of instilled carbon nanotubes in rat lung

BACKGROUND: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. METHODS: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel,...

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Autores principales: Elgrabli, Dan, Floriani, Magali, Abella-Gallart, Steve, Meunier, Laurent, Gamez, Christelle, Delalain, Patrice, Rogerieux, Françoise, Boczkowski, Jorge, Lacroix, Ghislaine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645433/
https://www.ncbi.nlm.nih.gov/pubmed/19068117
http://dx.doi.org/10.1186/1743-8977-5-20
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author Elgrabli, Dan
Floriani, Magali
Abella-Gallart, Steve
Meunier, Laurent
Gamez, Christelle
Delalain, Patrice
Rogerieux, Françoise
Boczkowski, Jorge
Lacroix, Ghislaine
author_facet Elgrabli, Dan
Floriani, Magali
Abella-Gallart, Steve
Meunier, Laurent
Gamez, Christelle
Delalain, Patrice
Rogerieux, Françoise
Boczkowski, Jorge
Lacroix, Ghislaine
author_sort Elgrabli, Dan
collection PubMed
description BACKGROUND: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. METHODS: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. RESULTS AND CONCLUSION: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.
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spelling pubmed-26454332009-02-20 Biodistribution and clearance of instilled carbon nanotubes in rat lung Elgrabli, Dan Floriani, Magali Abella-Gallart, Steve Meunier, Laurent Gamez, Christelle Delalain, Patrice Rogerieux, Françoise Boczkowski, Jorge Lacroix, Ghislaine Part Fibre Toxicol Research BACKGROUND: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. METHODS: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. RESULTS AND CONCLUSION: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration. BioMed Central 2008-12-09 /pmc/articles/PMC2645433/ /pubmed/19068117 http://dx.doi.org/10.1186/1743-8977-5-20 Text en Copyright © 2008 Elgrabli et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Elgrabli, Dan
Floriani, Magali
Abella-Gallart, Steve
Meunier, Laurent
Gamez, Christelle
Delalain, Patrice
Rogerieux, Françoise
Boczkowski, Jorge
Lacroix, Ghislaine
Biodistribution and clearance of instilled carbon nanotubes in rat lung
title Biodistribution and clearance of instilled carbon nanotubes in rat lung
title_full Biodistribution and clearance of instilled carbon nanotubes in rat lung
title_fullStr Biodistribution and clearance of instilled carbon nanotubes in rat lung
title_full_unstemmed Biodistribution and clearance of instilled carbon nanotubes in rat lung
title_short Biodistribution and clearance of instilled carbon nanotubes in rat lung
title_sort biodistribution and clearance of instilled carbon nanotubes in rat lung
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645433/
https://www.ncbi.nlm.nih.gov/pubmed/19068117
http://dx.doi.org/10.1186/1743-8977-5-20
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