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Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

The chemokine receptor CXCR4 plays important roles in the immune and nervous systems. Abnormal expression of CXCR4 contributes to cancer and inflammatory and neurodegenerative disorders. Although ligand-dependent CXCR4 ubiquitination is known to accelerate CXCR4 degradation, little is known about co...

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Detalles Bibliográficos
Autores principales:	Mines, Marjelo A., Goodwin, J. Shawn, Limbird, Lee E., Cui, Fei-Fei, Fan, Guo-Huang
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645827/ https://www.ncbi.nlm.nih.gov/pubmed/19106094 http://dx.doi.org/10.1074/jbc.M808507200

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