Cargando…

PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome

PURPOSE: To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS: Three single nucleotide polymorphism (SNPs), PD-1.3G/A, PD-1.5C/T, and PD-1.6G/A, were genotyped in 247 VKH patients and 289 age-, sex-, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Qianli, Liu, Xiaoli, Yang, Peizeng, Hou, Shengping, Du, Liping, Zhou, Hongyan, Kijlstra, Aize
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645903/
https://www.ncbi.nlm.nih.gov/pubmed/19234630
_version_ 1782164804259020800
author Meng, Qianli
Liu, Xiaoli
Yang, Peizeng
Hou, Shengping
Du, Liping
Zhou, Hongyan
Kijlstra, Aize
author_facet Meng, Qianli
Liu, Xiaoli
Yang, Peizeng
Hou, Shengping
Du, Liping
Zhou, Hongyan
Kijlstra, Aize
author_sort Meng, Qianli
collection PubMed
description PURPOSE: To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS: Three single nucleotide polymorphism (SNPs), PD-1.3G/A, PD-1.5C/T, and PD-1.6G/A, were genotyped in 247 VKH patients and 289 age-, sex-, and ethnically-matched healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The associations of genotypes and alleles with VKH syndrome were analyzed. RESULTS: All genotype distributions in healthy controls were in Hardy–Weinberg equilibrium. The genotype and allele frequencies of PD-1.3, PD-1.5, and PD-1.6 were not different between patients with VKH syndrome and healthy controls. No significant difference was observed according to the status of human leukocyte antigen (HLA)-DR4 and HLA-DRw53. Compared to the controls, lower frequencies of the PD-1.5C genotype and allele frequencies were observed in VKH patients with extraocular findings. CONCLUSIONS: PD-1.3 and PD-1.6 polymorphisms are not associated with the susceptibility to VKH syndrome in the Chinese Han population. However, PD-1.5 may be negatively associated with the occurrence of extraocular manifestations of VKH syndrome.
format Text
id pubmed-2645903
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Molecular Vision
record_format MEDLINE/PubMed
spelling pubmed-26459032009-02-22 PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome Meng, Qianli Liu, Xiaoli Yang, Peizeng Hou, Shengping Du, Liping Zhou, Hongyan Kijlstra, Aize Mol Vis Research Article PURPOSE: To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS: Three single nucleotide polymorphism (SNPs), PD-1.3G/A, PD-1.5C/T, and PD-1.6G/A, were genotyped in 247 VKH patients and 289 age-, sex-, and ethnically-matched healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The associations of genotypes and alleles with VKH syndrome were analyzed. RESULTS: All genotype distributions in healthy controls were in Hardy–Weinberg equilibrium. The genotype and allele frequencies of PD-1.3, PD-1.5, and PD-1.6 were not different between patients with VKH syndrome and healthy controls. No significant difference was observed according to the status of human leukocyte antigen (HLA)-DR4 and HLA-DRw53. Compared to the controls, lower frequencies of the PD-1.5C genotype and allele frequencies were observed in VKH patients with extraocular findings. CONCLUSIONS: PD-1.3 and PD-1.6 polymorphisms are not associated with the susceptibility to VKH syndrome in the Chinese Han population. However, PD-1.5 may be negatively associated with the occurrence of extraocular manifestations of VKH syndrome. Molecular Vision 2009-02-20 /pmc/articles/PMC2645903/ /pubmed/19234630 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meng, Qianli
Liu, Xiaoli
Yang, Peizeng
Hou, Shengping
Du, Liping
Zhou, Hongyan
Kijlstra, Aize
PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title_full PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title_fullStr PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title_full_unstemmed PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title_short PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
title_sort pdcd1 genes may protect against extraocular manifestations in chinese han patients with vogt-koyanagi-harada syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645903/
https://www.ncbi.nlm.nih.gov/pubmed/19234630
work_keys_str_mv AT mengqianli pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT liuxiaoli pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT yangpeizeng pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT houshengping pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT duliping pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT zhouhongyan pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome
AT kijlstraaize pdcd1genesmayprotectagainstextraocularmanifestationsinchinesehanpatientswithvogtkoyanagiharadasyndrome