Cargando…

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

OBJECTIVE—The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin. Because PTP1B(−/−) mice have diminished fat stores, the extent to which PTP1B directly regulates glucose homeostasis is unclear. Previou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delibegovic, Mirela, Zimmer, Derek, Kauffman, Caitlin, Rak, Kimberly, Hong, Eun-Gyoung, Cho, You-Ree, Kim, Jason K., Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646057/ https://www.ncbi.nlm.nih.gov/pubmed/19074988 http://dx.doi.org/10.2337/db08-0913

Ejemplares similares

Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
por: Fuentes, Federico, et al.
Publicado: (2012)

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor()
por: Tsou, Ryan C., et al.
Publicado: (2014)

Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis
por: Owen, Carl, et al.
Publicado: (2012)

Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis
por: Owen, Carl, et al.
Publicado: (2012)

The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
por: Tsou, Ryan C., et al.
Publicado: (2012)

Regulation of Signaling at Regions of Cell-Cell Contact by Endoplasmic Reticulum-Bound Protein-Tyrosine Phosphatase 1B
por: Haj, Fawaz G., et al.
Publicado: (2012)

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?
por: Vieira, Marcelo N. N., et al.
Publicado: (2017)

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE(−/−) mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
por: Thompson, D., et al.
Publicado: (2017)

Molecular docking and virtual screening for novel protein tyrosine phosphatase 1B (PTP1B) inhibitors
por: Rao, Pasupuleti Sreenivasa, et al.
Publicado: (2012)

Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives
por: Liu, Rongxing, et al.
Publicado: (2022)

Gene Expression of Protein Tyrosine Phosphatase 1B and Endoplasmic Reticulum Stress During Septic Shock
por: Clavier, Thomas, et al.
Publicado: (2019)

Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents
por: Onoda, Toshihisa, et al.
Publicado: (2014)

Protein tyrosine phosphatase 1B(PTP1B) promotes melanoma cells progression through Src activation
por: Wang, Qiang, et al.
Publicado: (2021)

Deletion of myeloid-PTP1B decreases MHC Class I expression and peptide presentation through an IL-10 dependent mechanism in response to LPS challenge
por: Le Sommer, Samantha, et al.
Publicado: (2015)

Protein tyrosine phosphatase, PTP1B, expression and activity in rat corneal endothelial cells
por: Harris, Deshea L., et al.
Publicado: (2007)

Coupling substrate-trapping with proximity-labeling to identify protein tyrosine phosphatase PTP1B signaling networks
por: Bonham, Christopher A., et al.
Publicado: (2023)

Protein Tyrosine Phosphatase-1B (PTP1B) Regulates EGF-induced Stimulation of Corneal Endothelial Cell Proliferation
por: Feizi, Sepehr
Publicado: (2009)

Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B
por: Sharma, Shivani, et al.
Publicado: (2023)

Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism
por: Oliver, Helk, et al.
Publicado: (2023)

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
por: Hoggard, Nigel, et al.
Publicado: (2012)

The Protein Tyrosine Phosphatase PTP1B Is Required for Efficient Delivery of N-Cadherin to the Cell Surface
por: Hernández, Mariana V., et al.
Publicado: (2010)

Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence
por: Ferrari, Emanuela, et al.
Publicado: (2011)

The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance
por: Abdelsalam, Shahenda S., et al.
Publicado: (2019)

Inhibition of Protein-Tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-Challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress
por: Bourebaba, Lynda, et al.
Publicado: (2020)

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge
por: Través, P G, et al.
Publicado: (2014)

Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products
por: Mascarello, Alessandra, et al.
Publicado: (2013)

ER-Bound Protein Tyrosine Phosphatase PTP1B Interacts with Src at the Plasma Membrane/Substrate Interface
por: Monteleone, Melisa C., et al.
Publicado: (2012)

Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa
por: Song, Yeong Hun, et al.
Publicado: (2017)

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR(−/−) mouse model of atherosclerosis
por: Thompson, Dawn, et al.
Publicado: (2017)

Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor
por: Fueller, Julia, et al.
Publicado: (2015)

Suggestion of suitable animal models for in vivo studies of protein tyrosine phosphatase 1b (PTP1B) inhibitors using computational approaches
por: Nguyen, Xuan Thi-Anh, et al.
Publicado: (2014)

Isolation and Characterization of Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Polyphenolic Compounds From Dodonaea viscosa and Their Kinetic Analysis
por: Uddin, Zia, et al.
Publicado: (2018)

Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis
por: Panzhinskiy, Evgeniy, et al.
Publicado: (2013)

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling
por: Penafuerte, Claudia, et al.
Publicado: (2017)

Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells
por: Ishino, Yutaka, et al.
Publicado: (2008)

Correction: Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor
por: Fueller, Julia, et al.
Publicado: (2016)

PTP1B regulates Eph receptor function and trafficking
por: Nievergall, Eva, et al.
Publicado: (2010)

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
Publicado: (1995)

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity
por: Medgyesi, David, et al.
Publicado: (2014)

Retraction: Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m726a8kgh252af54amgdusipo8