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Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation

OBJECTIVE—The endopeptidase dipeptidyl peptidase-IV (DPP-IV) has been shown to NH(2)-terminally truncate incretin hormones, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1, thus ablating their ability to potentiate glucose-stimulated insulin secretion. Increasing the circul...

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Detalles Bibliográficos
Autores principales:	Kim, Su-Jin, Nian, Cuilan, Doudet, Doris J., McIntosh, Christopher H.S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646063/ https://www.ncbi.nlm.nih.gov/pubmed/19073764 http://dx.doi.org/10.2337/db08-1101

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