Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

OBJECTIVE— Metformin, an oral glucose-lowering drug, is taken up in hepatocytes by the organic cation transporter (OCT) 1 and in renal epithelium by OCT2. In these cells, the multidrug and toxin extrusion (MATE) 1 protein, encoded by the SLC47A1 gene, is responsible for the excretion of metformin in...

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Detalles Bibliográficos
Autores principales: Becker, Matthijs L., Visser, Loes E., van Schaik, Ron H.N., Hofman, Albert, Uitterlinden, André G., Stricker, Bruno H.Ch.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646075/
https://www.ncbi.nlm.nih.gov/pubmed/19228809
http://dx.doi.org/10.2337/db08-1028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646075/
https://www.ncbi.nlm.nih.gov/pubmed/19228809
http://dx.doi.org/10.2337/db08-1028

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