Cargando…

Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes

OBJECTIVE— Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zobel, Dorit P., Andreasen, Camilla H., Grarup, Niels, Eiberg, Hans, Sørensen, Thorkild I.A., Sandbæk, Annelli, Lauritzen, Torsten, Borch-Johnsen, Knut, Jørgensen, Torben, Pedersen, Oluf, Hansen, Torben
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646077/ https://www.ncbi.nlm.nih.gov/pubmed/19073769 http://dx.doi.org/10.2337/db08-0620

Ejemplares similares

Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes
por: Andreasen, Camilla H., et al.
Publicado: (2008)

Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes
por: Andreasen, Camilla Helene, et al.
Publicado: (2009)

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
por: Andreasen, Camilla Helene, et al.
Publicado: (2008)

Implications of Central Obesity-Related Variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on Quantitative Metabolic Traits in Adult Danes
por: Bille, Dorthe S., et al.
Publicado: (2011)

No Consistent Effect of ADRB2 Haplotypes on Obesity, Hypertension and Quantitative Traits of Body Fatness and Blood Pressure among 6,514 Adult Danes
por: Gjesing, Anette P., et al.
Publicado: (2009)

Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes
por: Grarup, Niels, et al.
Publicado: (2008)

Studies of Metabolic Phenotypic Correlates of 15 Obesity Associated Gene Variants
por: Sandholt, Camilla Helene, et al.
Publicado: (2011)

Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case–control study
por: Hollensted, Mette, et al.
Publicado: (2015)

Correction: The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation
por: Krarup, Nikolaj Thure, et al.
Publicado: (2012)

The Type 2 Diabetes Associated Minor Allele of rs2237895 KCNQ1 Associates with Reduced Insulin Release Following an Oral Glucose Load
por: Holmkvist, Johan, et al.
Publicado: (2009)

Prevalence of Neuropathy and Peripheral Arterial Disease and the Impact of Treatment in People With Screen-Detected Type 2 Diabetes: The ADDITION-Denmark study
por: Charles, Morten, et al.
Publicado: (2011)

Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
por: Hansen, Tue H, et al.
Publicado: (2015)

The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation
por: Krarup, Nikolaj Thure, et al.
Publicado: (2012)

Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
por: Burgdorf, Kristoffer Sølvsten, et al.
Publicado: (2011)

Effect of population screening for type 2 diabetes and cardiovascular risk factors on mortality rate and cardiovascular events: a controlled trial among 1,912,392 Danish adults
por: Simmons, Rebecca K., et al.
Publicado: (2017)

Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
por: Snogdal, Lena Sønder, et al.
Publicado: (2013)

The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes
por: Harder, Marie Neergaard, et al.
Publicado: (2015)

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans
por: Andersson, Ehm A., et al.
Publicado: (2010)

The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
por: Banasik, Karina, et al.
Publicado: (2012)

Does training of general practitioners for intensive treatment of people with screen-detected diabetes have a spillover effect on mortality and cardiovascular morbidity in ‘at risk’ individuals with normoglycaemia? Results from the ADDITION-Denmark cluster-randomised controlled trial
por: Simmons, Rebecca K., et al.
Publicado: (2017)

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load
por: Hornbak, Malene, et al.
Publicado: (2011)

Effect of Intensive Multifactorial Treatment Compared With Routine Care on Aortic Stiffness and Central Blood Pressure Among Individuals With Screen-Detected Type 2 Diabetes: The ADDITION-Denmark study
por: Johansen, Nanna B., et al.
Publicado: (2012)

Bioinformatics-Driven Identification and Examination of Candidate Genes for Non-Alcoholic Fatty Liver Disease
por: Banasik, Karina, et al.
Publicado: (2011)

The Association of Alcohol and Alcohol Metabolizing Gene Variants with Diabetes and Coronary Heart Disease Risk Factors in a White Population
por: Husemoen, Lise Lotte N., et al.
Publicado: (2010)

Guideline-level monitoring, biomarker levels and pharmacological treatment in migrants and native Danes with type 2 diabetes: Population-wide analyses
por: Isaksen, Anders Aasted, et al.
Publicado: (2023)

Population-based studies of relationships between dietary acidity load, insulin resistance and incident diabetes in Danes
por: Gæde, Joachim, et al.
Publicado: (2018)

Combined Analyses of 20 Common Obesity Susceptibility Variants
por: Sandholt, Camilla Helene, et al.
Publicado: (2010)

Variation in CHI3LI in Relation to Type 2 Diabetes and Related Quantitative Traits
por: Rathcke, Camilla Noelle, et al.
Publicado: (2009)

Family and Population-Based Studies of Variation within the Ghrelin Receptor Locus in Relation to Measures of Obesity
por: Gjesing, Anette P., et al.
Publicado: (2010)

Progression to Impaired Glucose Regulation and Diabetes in the Population-Based Inter99 Study
por: Engberg, Susanne, et al.
Publicado: (2009)

Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes
por: Thomsen, Stine B., et al.
Publicado: (2015)

A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes
por: Hornbak, Malene, et al.
Publicado: (2014)

Comparison of Accuracy of Diabetes Risk Score and Components of the Metabolic Syndrome in Assessing Risk of Incident Type 2 Diabetes in Inter99 Cohort
por: Shafizadeh, Tracy B., et al.
Publicado: (2011)

Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome
por: Lohmueller, Kirk E., et al.
Publicado: (2011)

Change in cardiovascular risk factors following early diagnosis of type 2 diabetes: a cohort analysis of a cluster-randomised trial
por: Black, James A, et al.
Publicado: (2014)

Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial
por: Griffin, Simon J, et al.
Publicado: (2011)

Genetic markers of abdominal obesity and weight loss after gastric bypass surgery
por: Aasbrenn, Martin, et al.
Publicado: (2021)

Gran danés
por: Taragano de Azar, Rosa
Publicado: (1989)

Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report
por: Niazi, Robina Khan, et al.
Publicado: (2019)

Natural History of Insulin Sensitivity and Insulin Secretion in the Progression From Normal Glucose Tolerance to Impaired Fasting Glycemia and Impaired Glucose Tolerance: The Inter99 Study
por: Færch, Kristine, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_sp5sv969me40vfge1gm66ndtfv