Replication forks, chromatin loops and dormant replication origins

When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.

Detalles Bibliográficos
Autores principales: Blow, J Julian, Ge, Xin Quan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646269/
https://www.ncbi.nlm.nih.gov/pubmed/19144207
http://dx.doi.org/10.1186/gb-2008-9-12-244
Descripción
Sumario:When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.

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