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Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock

INTRODUCTION: Stimulation of beta(2)-adrenergic receptors (β(2)-ARs) inhibits tumor necrosis factor-alpha (TNF-α) release in monocytes. In septic shock, endogenous catecholamines induce β(2)-AR downregulation, leading to an increased TNF-α release. The aims of this study were to analyze the molecula...

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Detalles Bibliográficos
Autores principales:	Link, Andreas, Selejan, Simina, Maack, Christoph, Lenz, Monika, Böhm, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646324/ https://www.ncbi.nlm.nih.gov/pubmed/19091080 http://dx.doi.org/10.1186/cc7158

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