Releasing the spindle assembly checkpoint without tension

Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase...

Descripción completa

Detalles Bibliográficos
Autores principales: McEwen, Bruce F., Dong, Yimin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646545/
https://www.ncbi.nlm.nih.gov/pubmed/19193624
http://dx.doi.org/10.1083/jcb.200812016
_version_ 1782164855273291776
author McEwen, Bruce F.
Dong, Yimin
author_facet McEwen, Bruce F.
Dong, Yimin
author_sort McEwen, Bruce F.
collection PubMed
description Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase onset, the events triggering SAC release are poorly understood. Papers in this issue by Uchida et al. (Uchida, K.S.K., K. Takagaki, K. Kumada, Y. Hirayama, T. Noda, and T. Hirota. 2009. J. Cell Biol. 184:383–390) and Maresca and Salmon (Maresca, T.J., and E.D. Salmon. 2009. J. Cell Biol. 184:373–381) make an important advance by demonstrating that SAC release depends on molecular rearrangements within the kinetochore rather than tension-produced stretch between sister kinetochores.
format Text
id pubmed-2646545
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-26465452009-08-09 Releasing the spindle assembly checkpoint without tension McEwen, Bruce F. Dong, Yimin J Cell Biol Reviews Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase onset, the events triggering SAC release are poorly understood. Papers in this issue by Uchida et al. (Uchida, K.S.K., K. Takagaki, K. Kumada, Y. Hirayama, T. Noda, and T. Hirota. 2009. J. Cell Biol. 184:383–390) and Maresca and Salmon (Maresca, T.J., and E.D. Salmon. 2009. J. Cell Biol. 184:373–381) make an important advance by demonstrating that SAC release depends on molecular rearrangements within the kinetochore rather than tension-produced stretch between sister kinetochores. The Rockefeller University Press 2009-02-09 /pmc/articles/PMC2646545/ /pubmed/19193624 http://dx.doi.org/10.1083/jcb.200812016 Text en © 2009 McEwen and Dong This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
McEwen, Bruce F.
Dong, Yimin
Releasing the spindle assembly checkpoint without tension
title Releasing the spindle assembly checkpoint without tension
title_full Releasing the spindle assembly checkpoint without tension
title_fullStr Releasing the spindle assembly checkpoint without tension
title_full_unstemmed Releasing the spindle assembly checkpoint without tension
title_short Releasing the spindle assembly checkpoint without tension
title_sort releasing the spindle assembly checkpoint without tension
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646545/
https://www.ncbi.nlm.nih.gov/pubmed/19193624
http://dx.doi.org/10.1083/jcb.200812016
work_keys_str_mv AT mcewenbrucef releasingthespindleassemblycheckpointwithouttension
AT dongyimin releasingthespindleassemblycheckpointwithouttension

Ejemplares similares