Rethinking T cell immunity in oropharyngeal candidiasis

The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-in...

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Detalles Bibliográficos
Autores principales: Pirofski, Liise-anne, Casadevall, Arturo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646576/
https://www.ncbi.nlm.nih.gov/pubmed/19204107
http://dx.doi.org/10.1084/jem.20090093
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author Pirofski, Liise-anne
Casadevall, Arturo
author_facet Pirofski, Liise-anne
Casadevall, Arturo
author_sort Pirofski, Liise-anne
collection PubMed
description The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.
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spelling pubmed-26465762009-08-16 Rethinking T cell immunity in oropharyngeal candidiasis Pirofski, Liise-anne Casadevall, Arturo J Exp Med Commentary The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC. The Rockefeller University Press 2009-02-16 /pmc/articles/PMC2646576/ /pubmed/19204107 http://dx.doi.org/10.1084/jem.20090093 Text en © 2009 Pirofski and Casadevall This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Pirofski, Liise-anne
Casadevall, Arturo
Rethinking T cell immunity in oropharyngeal candidiasis
title Rethinking T cell immunity in oropharyngeal candidiasis
title_full Rethinking T cell immunity in oropharyngeal candidiasis
title_fullStr Rethinking T cell immunity in oropharyngeal candidiasis
title_full_unstemmed Rethinking T cell immunity in oropharyngeal candidiasis
title_short Rethinking T cell immunity in oropharyngeal candidiasis
title_sort rethinking t cell immunity in oropharyngeal candidiasis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646576/
https://www.ncbi.nlm.nih.gov/pubmed/19204107
http://dx.doi.org/10.1084/jem.20090093
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AT casadevallarturo rethinkingtcellimmunityinoropharyngealcandidiasis

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