Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, t...

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Detalles Bibliográficos
Autores principales: Schenten, Dominik, Kracker, Sven, Esposito, Gloria, Franco, Sonia, Klein, Ulf, Murphy, Michael, Alt, Frederick W., Rajewsky, Klaus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646585/
https://www.ncbi.nlm.nih.gov/pubmed/19204108
http://dx.doi.org/10.1084/jem.20080669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646585/
https://www.ncbi.nlm.nih.gov/pubmed/19204108
http://dx.doi.org/10.1084/jem.20080669

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