Cargando…

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schenten, Dominik, Kracker, Sven, Esposito, Gloria, Franco, Sonia, Klein, Ulf, Murphy, Michael, Alt, Frederick W., Rajewsky, Klaus
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646585/ https://www.ncbi.nlm.nih.gov/pubmed/19204108 http://dx.doi.org/10.1084/jem.20080669

Ejemplares similares

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions
por: Saribasak, Huseyin, et al.
Publicado: (2012)

Immunoglobulin class-switch recombination deficiencies
por: Durandy, Anne, et al.
Publicado: (2012)

The Function of AID in Somatic Mutation and Class Switch Recombination: Upstream or Downstream of DNA Breaks
por: Chua, Katrin F., et al.
Publicado: (2002)

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase—Pol ε Interaction
por: Denkiewicz-Kruk, Milena, et al.
Publicado: (2020)

AID overwhelms Polβ in class-switching B cells
por: Bashyam, Hema
Publicado: (2007)

Fixing DNA breaks during class switch recombination
por: Jolly, Christopher J., et al.
Publicado: (2008)

The effect of sequence context on spontaneous Polζ-dependent mutagenesis in Saccharomyces cerevisiae
por: Abdulovic, Amy L., et al.
Publicado: (2008)

Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ
por: McPherson, Kerry Silva, et al.
Publicado: (2022)

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
por: Manis, John P., et al.
Publicado: (1998)

The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability
por: Lange, Sabine S., et al.
Publicado: (2016)

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions
por: Hirota, Kouji, et al.
Publicado: (2010)

PP4 Is Essential for Germinal Center Formation and Class Switch Recombination in Mice
por: Chen, Ming-Yu, et al.
Publicado: (2014)

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
por: Franco, Sonia, et al.
Publicado: (2008)

Batf controls the global regulators of class switch recombination in both B and T cells
por: Ise, Wataru, et al.
Publicado: (2011)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
por: Dong, Junchao, et al.
Publicado: (2015)

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
por: Jeevan-Raj, Beena Patricia, et al.
Publicado: (2011)

The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair
por: Shimada, Kenji, et al.
Publicado: (2021)

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells
por: Bhat, Audesh, et al.
Publicado: (2013)

Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination
por: Oudinet, Chloé, et al.
Publicado: (2022)

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
por: Guikema, Jeroen E.J., et al.
Publicado: (2007)

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
por: Guikema, Jeroen E.J., et al.
Publicado: (2007)

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination
por: Nicolas, Laura, et al.
Publicado: (2018)

Pol II piece makes and breaks mRNA
por: Leslie, Mitch
Publicado: (2007)

Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching
por: Zarrin, Ali A., et al.
Publicado: (2008)

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N(2)-dG DNA adducts in yeast cells
por: Zhao, Bo, et al.
Publicado: (2006)

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N(2)-dG DNA adducts in yeast cells
por: Zhao, Bo, et al.
Publicado: (2006)

DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
por: Wu, Xiaoming, et al.
Publicado: (2007)

Fundamental Roles of Chromatin Loop Extrusion in Antibody Class Switching
por: Zhang, Xuefei, et al.
Publicado: (2019)

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism
por: Madia, Federica, et al.
Publicado: (2009)

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis
por: Makarova, Alena V., et al.
Publicado: (2012)

Human CD57(+ )germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination
por: Kim, Jong R, et al.
Publicado: (2005)

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination
por: Kadungure, Tatenda, et al.
Publicado: (2015)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses
por: Wang, Jing, et al.
Publicado: (2018)

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ
por: Tellier-Lebegue, Carine, et al.
Publicado: (2017)

MamPol: a database of nucleotide polymorphism in the Mammalia class
por: Egea, Raquel, et al.
Publicado: (2007)

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination
por: Bregenhorn, Stephanie, et al.
Publicado: (2016)

Physiological role of the 3′IgH CBEs super-anchor in antibody class switching
por: Zhang, Xuefei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bdr4tdth9doqg4dnd9vdn8lbh9