Interconversion of the cis-5R,6S- and trans-5R,6R-Thymine Glycol Lesions in Duplex DNA

[Image: see text] Thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, is formed in DNA by the reaction of thymine with reactive oxygen species. The 5R Tg lesion was incorporated site-specifically into 5′-d(G(1)T(2)G(3)C(4)G(5)Tg(6)G(7)T(8)T(9)T(10)G(11)T(12))-3′; Tg = 5R Tg. The Tg-modified oligo...

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Detalles Bibliográficos
Autores principales: Brown, Kyle L., Adams, Travis, Jasti, Vijay P., Basu, Ashis K., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646635/
https://www.ncbi.nlm.nih.gov/pubmed/18681438
http://dx.doi.org/10.1021/ja8016544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646635/
https://www.ncbi.nlm.nih.gov/pubmed/18681438
http://dx.doi.org/10.1021/ja8016544

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