Cargando…

Interconversion of the cis-5R,6S- and trans-5R,6R-Thymine Glycol Lesions in Duplex DNA

[Image: see text] Thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, is formed in DNA by the reaction of thymine with reactive oxygen species. The 5R Tg lesion was incorporated site-specifically into 5′-d(G(1)T(2)G(3)C(4)G(5)Tg(6)G(7)T(8)T(9)T(10)G(11)T(12))-3′; Tg = 5R Tg. The Tg-modified oligo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brown, Kyle L., Adams, Travis, Jasti, Vijay P., Basu, Ashis K., Stone, Michael P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2008
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646635/ https://www.ncbi.nlm.nih.gov/pubmed/18681438 http://dx.doi.org/10.1021/ja8016544

Ejemplares similares

The cis-(5R,6S)-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNA
por: Brown, Kyle L., et al.
Publicado: (2009)

Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5′-GTgG-3′ sequence: destabilization of two base pairs at the lesion site
por: Brown, Kyle L., et al.
Publicado: (2010)

Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA
por: Shimizu, Tatsuhiko, et al.
Publicado: (2006)

Rearrangement of the (6S,8R,11S) and (6R,8S,11R) Exocyclic 1,N(2)-Deoxyguanosine Adducts of trans-4-Hydroxynonenal to N(2)-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA
por: Huang, Hai, et al.
Publicado: (2008)

Mutagenicity and Genotoxicity of (5′S)-8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)-8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4
por: Pednekar, Varsha, et al.
Publicado: (2014)

Mutational Specificity of γ-Radiation-Induced Guanine−Thymine and Thymine−Guanine Intrastrand Cross-Links in Mammalian Cells and Translesion Synthesis Past the Guanine−Thymine Lesion by Human DNA Polymerase η
por: Colis, Laureen C., et al.
Publicado: (2008)

In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
por: van der Wilt, C. L., et al.
Publicado: (1993)

Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η
por: Raychaudhury, Paromita, et al.
Publicado: (2010)

Differential Stability of miR-9-5p and miR-9-3p in the Brain Is Determined by Their Unique Cis- and Trans-Acting Elements
por: Kim, C.K., et al.
Publicado: (2020)

Cis- and trans-regulation by histone H4 basic patch R17/R19 in metazoan development
por: Zhang, Xuedi, et al.
Publicado: (2022)

(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli
por: Jasti, Vijay P., et al.
Publicado: (2011)

(1R,6R)-1-Methyl-8-azaspiro[5.6]dodecan-7-one
por: Guéret, Stéphanie M., et al.
Publicado: (2008)

(1R*,2R*,4S*,5R*,6R*,8S*)-4,8-Dimethyl-2,6-diphenylbicyclo[3.3.1]nonane-2,6-diol
por: Nguyen, Vi T., et al.
Publicado: (2009)

(2E,4R,5R,6S)-2-(4,5,6-Trihydroxycyclohex-2-en-1-ylidene)acetonitrile
por: Guedem, Alphonsine N., et al.
Publicado: (2012)

Potential Stereoselective Binding of Trans-(±)-Kusunokinin and Cis-(±)-Kusunokinin Isomers to CSF1R
por: Chompunud Na Ayudhya, Chompunud, et al.
Publicado: (2022)

[(2R,5R,6S,9R)-6-Isopropyl-9-methyl-1,4-dioxaspiro[4.5]decan-2-yl]methyl 4-bromobenzoate
por: Kiessling, Anthony, et al.
Publicado: (2011)

(6R*,10R*)-Dimethyl 1,4-dioxaspiro[4.5]decane-6,10-dicarboxylate
por: Jahangiri, Amita, et al.
Publicado: (2013)

(6R)-2-tert-Butyl-6-[(4R,5S)-3-isopropyl-4-methyl-5-phenyloxazolidin-2-yl]phenol
por: Koyanagi, Takaoki, et al.
Publicado: (2010)

(5S*,6R*,7R*)-6-Formyl-5-phenyl-7-propylperhydropyrazolo[1,2-a]pyrazol-1-one
por: Yu, Jinlan, et al.
Publicado: (2010)

Ethyl (3S)-3-[(3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[4,5-d][1,3]dioxol-5-yl]-3-{(3S)-3-[(3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[4,5-d][1,3]dioxol-5-yl]-5-oxoisoxazolidin-2-yl}propanoate chloroform monosolvate
por: Amaro Hernández, Aldo Guillermo, et al.
Publicado: (2020)

(4R,5R,6S,7R,8S,9R,10S,13S)-7,8β-Epoxymomilactone-A
por: Shabnam Habib, Rana, et al.
Publicado: (2008)

(5S,6R)-5-Methyl-6-phenyl-4-propyl-1,3,4-oxadiazinane-2-thione
por: Kocher, Joshua L., et al.
Publicado: (2009)

(1R,3S,5R,6S)-6-Acetoxy-3-(4-methylphenylsulfonyloxy)tropane
por: Yang, Li-Min, et al.
Publicado: (2008)

(1R,3S,5R,6S)-6-Hydroxy-3-tosyloxytropan-8-ium chloride
por: Yu, Nian-Xi, et al.
Publicado: (2010)

R-chie: a web server and R package for visualizing cis and trans RNA–RNA, RNA–DNA and DNA–DNA interactions
por: Tsybulskyi, Volodymyr, et al.
Publicado: (2020)

(1R,4R,6S,7R)-5,5-Dibromo-1,4,8,8-tetramethyltricyclo[5.4.1.0(4,6)]dodecan-12-one
por: Zaki, Mohamed, et al.
Publicado: (2014)

(2S)-2-[(2S*,5R*,6R*)-5,6-Dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl]-1-[(S)-1,1-dimethylethylsulfonyl]aziridine
por: Moragas Solà, Toni, et al.
Publicado: (2010)

Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences
por: Weerasooriya, Savithri, et al.
Publicado: (2014)

MiR-21-5p protects against ischemic stroke by targeting IL-6R
por: Zhan, Lan, et al.
Publicado: (2023)

Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
por: Wang, Jixiu, et al.
Publicado: (2022)

Comparative effect of 6S, 6R and 6RS leucovorin on methotrexate rescue and on modulation of 5-fluorouracil.
por: Zittoun, J., et al.
Publicado: (1991)

Superiority of the Triple-Acting 5-HT(6)R/5-HT(3)R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT(6)R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
por: Grychowska, Katarzyna, et al.
Publicado: (2023)

Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma
por: Okada, Reona, et al.
Publicado: (2020)

{(3aR,5S,6R,6aR)-5-[(R)-1,2-Dihydroxyethyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-yl}methyl methanesulfonate
por: Rjabovs, Vitālijs, et al.
Publicado: (2014)

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
por: Bellon, Sophie, et al.
Publicado: (2009)

Dynamics of 5R-Tg Base Flipping in DNA Duplexes Based on Simulations—Agreement with Experiments and Beyond
por: Wang, Shu dong, et al.
Publicado: (2022)

High-Energy Long-Lived Emitting Mixed Excitons in Homopolymeric Adenine-Thymine DNA Duplexes
por: Vayá, Ignacio, et al.
Publicado: (2022)

(1R,6R,13R,18R)-(Z,Z)-1,18-Bis[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3,16-dimethylene-8,20-diazadispiro[5.6.5.6]tetracosa-7,19-diene
por: Guéret, Stéphanie M., et al.
Publicado: (2010)

Tobacco-Specific Nitrosamine-Derived O(2)-Alkylthymidines Are Potent Mutagenic Lesions in SOS-Induced Escherichia coli
por: Jasti, Vijay P., et al.
Publicado: (2011)

(3S,5R,6S)-Diphenylmethyl 1-oxo-6-bromopenicillanate
por: Soundararajan, Krishnan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hihhvj528rv4q3utv2gsrc9deo