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An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)

A novel and integral approach to the understanding of human neurodegenerative diseases (HNDDs) and cancer based upon the disruption of the intracellular dynamics of the hydrogen ion (H(+)) and its physiopathology, is advanced. From an etiopathological perspective, the activity and/or deficiency of d...

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Detalles Bibliográficos
Autores principales: Harguindey, Salvador, Orive, Gorka, Cacabelos, Ramón, Hevia, Enrique Meléndez, de Otazu, Ramón Díaz, Arranz, Jose Luis, Anitua, Eduardo
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646641/
https://www.ncbi.nlm.nih.gov/pubmed/19337452
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author Harguindey, Salvador
Orive, Gorka
Cacabelos, Ramón
Hevia, Enrique Meléndez
de Otazu, Ramón Díaz
Arranz, Jose Luis
Anitua, Eduardo
author_facet Harguindey, Salvador
Orive, Gorka
Cacabelos, Ramón
Hevia, Enrique Meléndez
de Otazu, Ramón Díaz
Arranz, Jose Luis
Anitua, Eduardo
author_sort Harguindey, Salvador
collection PubMed
description A novel and integral approach to the understanding of human neurodegenerative diseases (HNDDs) and cancer based upon the disruption of the intracellular dynamics of the hydrogen ion (H(+)) and its physiopathology, is advanced. From an etiopathological perspective, the activity and/or deficiency of different growth factors (GFs) in these pathologies are studied, and their relationships to intracellular acid-base homeostasis reviewed. Growth and trophic factor withdrawal in HNDDs indicate the need to further investigate the potential utilization of certain GFs in the treatment of Alzheimer disease and other neurodegenerative diseases. Platelet abnormalities and the therapeutic potential of platelet-derived growth factors in these pathologies, either through platelet transfusions or other clinical methods, are considered. Finally, the etiopathogenic mechanisms of apoptosis and antiapoptosis in HNDDs and cancer are viewed as opposite biochemical and biological disorders of cellular acid-base balance and their secondary effects on intracellular signaling pathways and aberrant cell metabolism are considered in the light of the both the seminal and most recent data available. The “trophic factor withdrawal syndrome” is described for the first time in English-speaking medical literature, as well as a Darwinian-like interpretation of cellular behavior related to specific and nonspecific aspects of cell biology.
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spelling pubmed-26466412009-04-01 An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS) Harguindey, Salvador Orive, Gorka Cacabelos, Ramón Hevia, Enrique Meléndez de Otazu, Ramón Díaz Arranz, Jose Luis Anitua, Eduardo Neuropsychiatr Dis Treat Review A novel and integral approach to the understanding of human neurodegenerative diseases (HNDDs) and cancer based upon the disruption of the intracellular dynamics of the hydrogen ion (H(+)) and its physiopathology, is advanced. From an etiopathological perspective, the activity and/or deficiency of different growth factors (GFs) in these pathologies are studied, and their relationships to intracellular acid-base homeostasis reviewed. Growth and trophic factor withdrawal in HNDDs indicate the need to further investigate the potential utilization of certain GFs in the treatment of Alzheimer disease and other neurodegenerative diseases. Platelet abnormalities and the therapeutic potential of platelet-derived growth factors in these pathologies, either through platelet transfusions or other clinical methods, are considered. Finally, the etiopathogenic mechanisms of apoptosis and antiapoptosis in HNDDs and cancer are viewed as opposite biochemical and biological disorders of cellular acid-base balance and their secondary effects on intracellular signaling pathways and aberrant cell metabolism are considered in the light of the both the seminal and most recent data available. The “trophic factor withdrawal syndrome” is described for the first time in English-speaking medical literature, as well as a Darwinian-like interpretation of cellular behavior related to specific and nonspecific aspects of cell biology. Dove Medical Press 2008-12 /pmc/articles/PMC2646641/ /pubmed/19337452 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Review
Harguindey, Salvador
Orive, Gorka
Cacabelos, Ramón
Hevia, Enrique Meléndez
de Otazu, Ramón Díaz
Arranz, Jose Luis
Anitua, Eduardo
An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title_full An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title_fullStr An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title_full_unstemmed An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title_short An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)
title_sort integral approach to the etiopathogenesis of human neurodegenerative diseases (hndds) and cancer. possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (tfws)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646641/
https://www.ncbi.nlm.nih.gov/pubmed/19337452
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