A Role for Confined Water in Chaperonin Function

[Image: see text] Chaperonins engulf other proteins and accelerate their folding by an unknown mechanism. Here, we combine all-atom molecular dynamics simulations with data from experimental assays of the activity of the bacterial chaperonin GroEL to demonstrate that a chaperonin’s ability to facili...

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Detalles Bibliográficos
Autores principales: England, Jeremy L., Lucent, Del, Pande, Vijay S.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646679/
https://www.ncbi.nlm.nih.gov/pubmed/18710231
http://dx.doi.org/10.1021/ja802248m
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author England, Jeremy L.
Lucent, Del
Pande, Vijay S.
author_facet England, Jeremy L.
Lucent, Del
Pande, Vijay S.
author_sort England, Jeremy L.
collection PubMed
description [Image: see text] Chaperonins engulf other proteins and accelerate their folding by an unknown mechanism. Here, we combine all-atom molecular dynamics simulations with data from experimental assays of the activity of the bacterial chaperonin GroEL to demonstrate that a chaperonin’s ability to facilitate folding is correlated with the affinity of its interior surface for water. Our results suggest a novel view of the behavior of confined water for models of in vivo protein folding scenarios.
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spelling pubmed-26466792009-03-20 A Role for Confined Water in Chaperonin Function England, Jeremy L. Lucent, Del Pande, Vijay S. J Am Chem Soc [Image: see text] Chaperonins engulf other proteins and accelerate their folding by an unknown mechanism. Here, we combine all-atom molecular dynamics simulations with data from experimental assays of the activity of the bacterial chaperonin GroEL to demonstrate that a chaperonin’s ability to facilitate folding is correlated with the affinity of its interior surface for water. Our results suggest a novel view of the behavior of confined water for models of in vivo protein folding scenarios. American Chemical Society 2008-08-19 2008-09-10 /pmc/articles/PMC2646679/ /pubmed/18710231 http://dx.doi.org/10.1021/ja802248m Text en Copyright © 2008 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. 40.75
spellingShingle England, Jeremy L.
Lucent, Del
Pande, Vijay S.
A Role for Confined Water in Chaperonin Function
title A Role for Confined Water in Chaperonin Function
title_full A Role for Confined Water in Chaperonin Function
title_fullStr A Role for Confined Water in Chaperonin Function
title_full_unstemmed A Role for Confined Water in Chaperonin Function
title_short A Role for Confined Water in Chaperonin Function
title_sort role for confined water in chaperonin function
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646679/
https://www.ncbi.nlm.nih.gov/pubmed/18710231
http://dx.doi.org/10.1021/ja802248m
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