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Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Ca(v)α(2)δ(1)) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neuroplasticity modulates behavioral hypersensitivity by regulating spinal glutamatergic...

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Detalles Bibliográficos
Autores principales:	Nguyen, David, Deng, Ping, Matthews, Elizabeth A, Kim, Doo-Sik, Feng, Guoping, Dickenson, Anthony H, Xu, Zao C, Luo, Z David
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646710/ https://www.ncbi.nlm.nih.gov/pubmed/19216737 http://dx.doi.org/10.1186/1744-8069-5-6

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