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Biological activity of a genetically modified BMP-2 variant with inhibitory activity

BACKGROUND: Alterations of the binding epitopes of bone morphogenetic protein-2 (BMP-2) lead to a modified interaction with the ectodomains of BMP receptors. In the present study the biological effect of a BMP-2 double mutant with antagonistic activity was evaluated in vivo. METHODS: Equine-derived...

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Detalles Bibliográficos
Autores principales:	Klammert, Uwe, Nickel, Joachim, Würzler, Kristian, Klingelhöffer, Christoph, Sebald, Walter, Kübler, Alexander C, Reuther, Tobias
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646720/ https://www.ncbi.nlm.nih.gov/pubmed/19187528 http://dx.doi.org/10.1186/1746-160X-5-6

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