The Stereochemistry of trans-4-Hydroxynonenal-Derived Exocyclic 1,N(2)-2′-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-Links in the 5′-CpG-3′ Sequence

[Image: see text] The trans-4-hydroxynonenal (HNE)-derived exocyclic 1,N(2)-dG adduct with (6S,8R,11S) stereochemistry forms interstrand N(2)-dG−N(2)-dG cross-links in the 5′-CpG-3′ DNA sequence context, but the corresponding adduct possessing (6R,8S,11R) stereochemistry does not. Both exist primari...

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Detalles Bibliográficos
Autores principales: Huang, Hai, Wang, Hao, Qi, Nan, Lloyd, R. Stephen, Rizzo, Carmelo J., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646759/
https://www.ncbi.nlm.nih.gov/pubmed/18847226
http://dx.doi.org/10.1021/bi8011143

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