Rearrangement of the (6S,8R,11S) and (6R,8S,11R) Exocyclic 1,N(2)-Deoxyguanosine Adducts of trans-4-Hydroxynonenal to N(2)-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA

[Image: see text] trans-4-Hydroxynonenal (HNE) is a peroxidation product of ω-6 polyunsaturated fatty acids. The Michael addition of deoxyguanosine to HNE yields four diastereomeric exocyclic 1,N(2)-dG adducts. The corresponding acrolein- and crotonaldehyde-derived exocyclic 1,N(2)-dG adducts underg...

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Detalles Bibliográficos
Autores principales: Huang, Hai, Wang, Hao, Qi, Nan, Kozekova, Albena, Rizzo, Carmelo J., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646763/
https://www.ncbi.nlm.nih.gov/pubmed/18661996
http://dx.doi.org/10.1021/ja801824b

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