Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

[Image: see text] Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunction...

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Detalles Bibliográficos
Autores principales: Di Santo, Roberto, Costi, Roberta, Roux, Alessandra, Miele, Gaetano, Crucitti, Giuliana Cuzzucoli, Iacovo, Alberto, Rosi, Federica, Lavecchia, Antonio, Marinelli, Luciana, Di Giovanni, Carmen, Novellino, Ettore, Palmisano, Lucia, Andreotti, Mauro, Amici, Roberta, Galluzzo, Clementina Maria, Nencioni, Lucia, Palamara, Anna Teresa, Pommier, Yves, Marchand, Christophe
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646871/
https://www.ncbi.nlm.nih.gov/pubmed/18646746
http://dx.doi.org/10.1021/jm8001422

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