Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media

[Image: see text] We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2′-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic deri...

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Autores principales: García-Arriaga, Marilyn, Hobley, Gerard, Rivera, José M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646872/
https://www.ncbi.nlm.nih.gov/pubmed/18642917
http://dx.doi.org/10.1021/ja8039019
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author García-Arriaga, Marilyn
Hobley, Gerard
Rivera, José M.
author_facet García-Arriaga, Marilyn
Hobley, Gerard
Rivera, José M.
author_sort García-Arriaga, Marilyn
collection PubMed
description [Image: see text] We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2′-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.
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spelling pubmed-26468722009-03-20 Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media García-Arriaga, Marilyn Hobley, Gerard Rivera, José M. J Am Chem Soc [Image: see text] We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2′-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media. American Chemical Society 2008-07-22 2008-08-13 /pmc/articles/PMC2646872/ /pubmed/18642917 http://dx.doi.org/10.1021/ja8039019 Text en Copyright © 2008 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. 40.75
spellingShingle García-Arriaga, Marilyn
Hobley, Gerard
Rivera, José M.
Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title_full Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title_fullStr Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title_full_unstemmed Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title_short Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
title_sort isostructural self-assembly of 2′-deoxyguanosine derivatives in aqueous and organic media
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646872/
https://www.ncbi.nlm.nih.gov/pubmed/18642917
http://dx.doi.org/10.1021/ja8039019
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AT riverajosem isostructuralselfassemblyof2deoxyguanosinederivativesinaqueousandorganicmedia

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